Thanks Bryan, great piece, you raised really good points (and concerns).
I think is paramount for entrepreneurs to start thinking in terms of uncertainty management rather than pure metrics maximization, while as a society we should likely not only learn how to learn but also (and especially) how to unlearn.
This would give us the power to design ‘thought experiments’ based on different assumptions (in the same fashion Einstein did) and to overcome what we believe to be the current physical and mental barriers given by what we (think we) know.